Drug interaction (18. combination with antihypertensive)

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I Brazilian Position Paper on Antihypertensive Drug Combination

Arterial hypertension (AH) is a highly prevalent disease, and is a major cardiovascular (CV) risk factor 1 ; therefore, achieving blood pressure (BP) control goals as soon as possible is paramount to reduce that risk 2. That means that approximately 70% of hypertensive individuals will need antihypertensive drug combination 3 , and up to 30% of hypertensive individuals are estimated to use four...

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Combination Therapy in Antihypertensive Treatment

One of the most prevalent and important disease worldwide is arterial hypertension with prevalence of 35-40%. When we look worldwide prevalence of hypertension in 2000, we can see that approximately 972 millions of people were with hypertension, and the estimation is that around 1560 millions of people in 2025 will have hypertension [1]. There is a linear association between increased blood pre...

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Drug interactions of antihypertensive agents

Adverse drug-drug interactions may occur when a major therapeutic mechanism of one drug class (such as bradycardia with a beta blocker) is excessively exaggerated by the addition of another heart-rate slowing antihypertensive, such as verapamil. The most important interactions at the molecular level are those of the hepatic enzyme, cytochrome (CYP) 3A4. A classic example is the inhibitory effec...

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Persistence to antihypertensive drug classes

The aim was to study persistence to, and switching between, antihypertensive drug classes and to determine factors associated with poor persistence.This was an observational cohort study. The Swedish Primary Care Cardiovascular Database includes data from medical records, socioeconomic data, filled prescriptions, and hospitalizations from national registries for 75,000 patients with hypertensio...

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Trends in antihypertensive drug treatment.

To the Editor: It is disappointing to read once again that “b-blockers and thiazide diuretics are the only antihypertensive agents that have been shown to reduce cardiovascular mortality.”1 In these days of evidence-based medicine, we must ask: where is the evidence for this statement? The basic data referenced by Wang et al1 are those of the meta-analysis of Psaty et al,2 which are also shown ...

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ژورنال

عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)

سال: 2010

ISSN: 0030-1558,1882-4528

DOI: 10.4044/joma.122.163